236 - A Case-control Study on Diagnostic and Biomarker Utility of NODDI in P...

General Session: Diagnostic Imaging

Presented by: W. Tian


W. Tian(1), J. Wang(1), X. Han(1), D. Li(1), G. Li(2), Q. Song(1)

(1) Fourth Clinical Medical College of Peking University, Beijing Jishuitan Hospital, Department of Spine Surgery, Beijing, China
(2) Tsinghua University, Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Beijing, China


Background data:Neurite orientation dispersion and density imaging (NODDI) is a biophysically plausible models developed for estimating neurite density and orientation dispersion separately. Until now, there are few research on the diagnostic and biomarker utility of NODDI in degenerative cervical myelopathy (DCM) patients. Purpose:To preliminary investigate the diagnostic and biomarker utility of NODDI in postoperative patients.

Study Design: A case-control study. Subjects and

Methods: 59 postoperative DCM patients who were 222 to 727 days after surgery were recruited as case group, as well as 21 healthy volunteers for control group. NODDI data were acquired on the axial view, with 17 slices in total covering the vertebral levels from C2 to C7. NODDI parameters volume of intra-cellular fraction (Vicf) and orientation dispersion index (ODI) were measured at levels of maximal compression (LMC) of case group and corresponding levels of control group. Symptoms and signs were noted to identify myelopathy, JOA scale was used to assess spinal function status. Using one-tailed t-test to compare Vicf and ODI between two groups. Receiver-operator characteristic (ROC) analysis and spearman's correlation were used to determine the diagnostic and biomarker utility of NODDI parameters. The level of significance was set at P< 0.05. All data analyses were performed using SPSS 20.

Results: All subjects in case group were identified myelopathy, with JOA scores from 11.5 to 17 points. The one-tailed t-test showed that there were significant decrease in Vicf at LMCs of case group when compared with corresponding levels of control group. As for ODI, there were no significant difference except at C5/6, where the ODI in case group were less than control group. The area under the ROC curves of Vicf in each level and ODI at C5/6 were more than 0.7. Spearman's correlation show that Vicf was significantly correlated with JOA (ρ=0.397), but ODI was not.

Conclusion: The NODDI parameters Vicf, describing neurite density, could diagnosis and evaluate postoperative DCM patients, while ODI, describing neurite orientation dispersion could not.